Nat Faxon

Captain Underpants / Mr. Krupp / Buffalobe (voice)

Jay Gragnani

Harold Hutchins (voice)

Ramone Hamilton

George Beard / Young Mr. Cleveland (voice)

Sean Astin

Narrator / Putter Mulligan (voice)

Dayci Brookshire

Jessica / Dressy / Smartaconda (voice)

Jorge Diaz

Melvin / Stanley Peet (voice)

Todd Grimes

Benjamin Franklin (voice)

Peter Hastings

Comic Narrator / Marlin (voice)

Evan Kishiyama

Steve "Gooch" Yamaguchi (voice)

David Koechner

Mr. Meaner (voice)